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In this video, we will be looking at the efficacy of microdosing finasteride. We’ll look into how well 0.2mg stacks up against the manufacture recommended 1mg dosage.
Make sure to leave a comment – we love to hear from you guys and your thoughts on microdosing finasteride!
00:38 – Introduction
1:45 – What is Finasteride? How does it work?
3:35 – Study 1: The Effects of Finasteride on Scalp Skin and Serum Androgen Levels
5:23 – Study 2: Clinical dose ranging studies with finasteride
5:49 – Study 3: Finasteride in the treatment of Japanese men with MPHL.
6:30 – Meta-Analysis: Adverse Event Reporting in Clinical Trials of Finasteride for Androgenic Alopecia
6:39 – Why Did Merck Approve 1mg?
7:05 – Study 5: The Effect of Finasteride in Men with BPH
7:33 – Merck’s Clinical Trials
7:51 – Study 6: Finasteride in the treatment of men with androgenetic alopecia.
8:57 – What Dosage Is Best?
9:49 – More Information On Clinical Trials
11:36 – Time Frames For Clinical Trials
13:01 – Health Canada Warning
13:44 – Meta Analysis: Adverse Event Reporting in Clinical Trials of Finasteride for Androgenic Alopecia
Study 1: The effects of finasteride on scalp skin and serum androgen levels in men with androgenetic alopecia:
Study 2: Clinical dose ranging studies with finasteride, a type 2 5alpha-reductase inhibitor, in men with male pattern hair loss –
Study 3: Finasteride in the treatment of Japanese men with male pattern hair loss.
Review Article: Adverse Event Reporting in Clinical Trials of Finasteride for Androgenic Alopecia
Study 4: Meta-Analysis: Adverse Event Reporting in Clinical Trials of Finasteride for Androgenic Alopecia: A Meta-analysis.
Study 5: The Effect of Finasteride in Men with BPH
Study 6: Finasteride in the treatment of men with androgenetic alopecia.
Health Canada Warning:
Meta Analysis: Adverse Event Reporting in Clinical Trials of Finasteride for Androgenic Alopecia
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In today’s video we will be discussing the merits of taking a dosage of finasteride smaller than the manufacturer recommended 1mg daily.
And by smaller I mean 5 times smaller, or 0.2mg daily to be exact.
Now on the face of it this might seem excessive, even absurd: why take a drug at one fifth the recommended dosage? Surely this will render it useless, no?
Well, not so fast.
Believe it or not, there is solid evidence to suggest that the five times smaller dosage will be almost as effective, if not just as effective.
We have a lot to cover in today’s video, so let’s get straight into it.
Briefly, what is Finasteride? Finasteride is the only FDA-approved oral medication for the treatment of male pattern baldness. It is also approved for the treatment of benign prostate enlargement.
It’s sold by Merck under the brand names Propecia for baldness and Proscar for prostate enlargement, though you can also find generic versions from various other manufacturers.
The Propecia tablets each contain 1mg of finasteride, while those of Proscar are 5mg each.
Now finasteride works by blocking the metabolism of DHT, which is the primary molecule implicated in male pattern baldness.
DHT attacks the hair follicles on the frontal and vertex areas of the scalp, shortening the length of the follicles’ growth phase.
Eventually DHT causes the follicles to miniaturize and stop producing terminal hairs altogether, leading to complete baldness.
DHT is converted from the testosterone that we all have flowing through our bodies via two enzymes. These two enzymes have a slightly different structure but identical function, and they are called type one 5-alpha-reductase and type two 5-alpha-reductase.
Only the type two 5-alpha-reductase is implicated in male pattern baldness, and finasteride works by binding specifically to this enzyme, not the type 1.
This video is for educational purposes only and is not intended to treat, diagnose or cure any disease.